humoral immunity to human neoplasms

Intrathecal Humoral Immunity to Encephalitic RNA Viruses

The nervous system is the target for acute encephalitic viral infections, as well as a reservoir for persisting viruses. Intrathecal antibody (Ab) synthesis is well documented in humans afflicted by infections associated with neurological complications, as well as the demyelinating disease, multiple sclerosis. This review focuses on the origin, recruitment, maintenance, and biological relevance...

Humoral and cell-mediated immunity to cytomegaloviruses.

Specific immunologic resistance mechanisms to cytomegalovirus (CMV) have not been extensively studied in either normal subjects or immunosuppressed renal allograft recipients. Such studies are in progress in my laboratory. Humoral immunity to CMV appears to be unimpaired in infected transplant patients. The neutralizing (NT) antibody titers in 24 allograft recipients with active CMV infection w...

Sculpting humoral immunity through dengue vaccination to enhance protective immunity

Dengue viruses (DENV) are the most important mosquito transmitted viral pathogens infecting humans. DENV infection produces a spectrum of disease, most commonly causing a self-limiting flu-like illness known as dengue fever; yet with increased frequency, manifesting as life-threatening dengue hemorrhagic fever (DHF). Waning cross-protective immunity from any of the four dengue serotypes may enh...

Humoral immunity in cardiomyopathy.

Sera from patients with heart disease were examined by single sandwich indirect immunofluorescence for the presence of antibodies to human heart muscle. Endocardial biopsy specimens were also examined by direct immunofluorescence for deposition of antibodies in vivo. No consistent or specific abnormality was found in the biopsy specimens or sera of patients with congestive cardiomyopathy. The p...

Cellular and Humoral Immunity

The Abstract was presented at the Fourth Herpes Virus Meeting, Cold Spring Harbor, N. Y. Dr. Pollard's present address is Division of Infectious Diseases, University of Texas Medical Branch, Galveston, Texas. Received for publicatiotn 2 October 1979 anid inl revised forimi 14 December 1979. recovery of phytohemagglutinin transformation often preceded recovery of the responses to viral antigens....

Persisting Humoral Antiviral Immunity